The Promise of Chromovert® Technology
Chromovert® Technology is a cell engineering method originating from The Rockefeller University that scans millions of cells to detect and isolate even exceedingly rare, optimally engineered cells.
Chromovert® Technology is a cell engineering method originating from The Rockefeller University that scans millions of cells to detect and isolate even exceedingly rare, optimally engineered cells.
Both can automate and improve systems. Multiple AI's are under development, but only our Chromovert® wet-lab cell array discovery platform can uniquely marry, validate and further propel in silico AI results to the stratosphere.
Chromovert® Technology
Chromovert® is a platform biotechnology that may be applied to any gene, any cell. The method is based on the broadly-applicable principles of fluorescence resonance energy transfer (FRET) and nucleic acid hybridization.
Add one or more target genes to cells
Use Molecular Beacons to light up cells that have taken up high levels of all added genes.
Use cell sorting to scan hundreds of millions of cells to purify the cream of the crop, and miniaturized automated robotics to maintain, test, and produce final optimally engineered clones.
Chromo-Tags™ streamline the cell engineering process by obviating the need to design and develop gene-specific probes.
Chromo-Tags™ allow a "plug and play" approach to using Chromovert® Technology. Chromo-Tags™ are 3' untranslated RNA sequence tags subcloned for expression downstream of the stop codon of cDNAs of interest. Unlike epitope tags that decorate polypeptides at the amino acid level, Chromo-Tags™ are not translated into protein, such that only native protein sequences are expressed.
Cell discovery offers multiple touchpoints for Data Analytics, Machine Learning & AI. Chromovert® marries them all.
What sets us apart from all others is our proprietary Chromovert®-enabled cell arrays shown to uniquely mimic natural human biology for physiological-relevant cell models for reliable results when pairing, correlating and validating in silicio designs.
From proprietary analytics to produce final cell and testing conditions to Machine Learning and AI to guide structure and activity optimization of drug candidates, Chromovert® wet-lab cell arrays provide the competitive edge stitch when to reliably stitch it all together.
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We specialize in making cells for notoriously toxic genes, complexes of multiple proteins, and proteins that are difficult to otherwise express in their full-length and native form, exactly as they exist in nature.
Until now, shortcuts and modifications were required to access these genes, resulting in a 98% average failure rate across the drug discovery industry. By gaining access to genes as they exist in the body, Chromovert® Technology engine improves the overall likelihood of success and the cost-effectiveness of drug discovery.
Comparison to competitor results demonstrate that only Chromovert® Technology recapitulates human physiology with greater fidelity than previously reported.
